Premium
Fluorophore‐Labeled Siloxane‐Based Nanoparticles for Biomedical Applications
Author(s) -
Koshkina Olga,
Bantz Christoph,
Würth Christian,
Lang Thomas,
ReschGenger Ute,
Maskos Michael
Publication year - 2011
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201100041
Subject(s) - fluorophore , siloxane , nanoparticle , materials science , polymer chemistry , fluorescence , coating , monomer , polymerization , surface modification , rhodamine , covalent bond , polymer , chemical engineering , chemistry , nanotechnology , organic chemistry , engineering , composite material , physics , quantum mechanics
We present the synthesis and characterization of multifunctional fluorophore‐labeled poly(organosiloxane) nanoparticles with core‐shell architecture, where the fluorescent dye is incorporated into the core. Grafting of heterobifunctional poly(ethylene oxide) (PEO) onto the particle surface leads to water‐soluble biocompatible nanoparticles. Two different strategies have been used for the synthesis: The encapsulation of dye‐labeled monomers during the polycondensation with additional PEO coating and subsequent dye labeling by covalent attachment of the fluorescent dye rhodamine B to the (chloromethylphenyl)siloxane groups in the core after polymerization and grafting of PEO onto the surface. Comparison of the fluorescence quantum yields of the nanoparticles before and after PEO coating show a decrease in quantum yield after PEO coating.