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Development of Mechanically Tailored Gelatin‐Chondroitin Sulphate Hydrogel Films
Author(s) -
Van Vlierberghe Sandra,
Samal Sangram Keshari,
Dubruel Peter
Publication year - 2011
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201100030
Subject(s) - gelatin , self healing hydrogels , methacrylamide , materials science , chemical engineering , chondroitin , rheology , polymer , polymer chemistry , methacrylate , chemistry , composite material , organic chemistry , copolymer , acrylamide , glycosaminoglycan , engineering , biochemistry
The aim of the present work was to develop and characterize biohybrid hydrogels containing combinations of gelatin and chondroitin sulphate. Two approaches have been compared. First, physisorption of chondroitin sulphate to gelatin hydrogels was investigated using surface plasmon resonance measurements. Due to the limited interaction between both biopolymers, we developed in a second approach methacrylate‐modified chondroitin sulphate hydrogels as such or in combination with methacrylamide‐modified gelatin. Rheology measurements indicated that following this approach, mechanically stable hydrogel films could be obtained after UV irradiation in the presence of Irgacure 2959 as UV photo‐initiator. When keeping the gelatin concentration and the modification degree constant, an increase in derivatization of the chondroitin sulphate component resulted in a high increase of the storage modulus.