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New Route to Polymeric Nanoparticles by Click Chemistry Using Bifunctional Cross‐Linkers
Author(s) -
de Luzuriaga Alaitz Ruiz,
PerezBaena Irma,
Montes Sarah,
Loinaz Iraida,
Odriozola Ibon,
García Ignacio,
Pomposo José A.
Publication year - 2010
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201051042
Subject(s) - bifunctional , chain transfer , raft , polymer chemistry , reversible addition−fragmentation chain transfer polymerization , chemistry , polymerization , click chemistry , copolymer , radical polymerization , azide , nanoparticle , cycloaddition , polystyrene , polymer , organic chemistry , materials science , nanotechnology , catalysis
A new route to functional polymeric nanoparticles (PNPs) of different chemical nature in the 3 to 20 nm size range is reported by combining both radical addition fragmentation chain transfer (RAFT) polymerization and “click” chemistry (CC) techniques. RAFT polymerization was employed for the synthesis of well‐defined statistical copolymers with pending –Cl groups along the macromolecular chain. After transformation of the –Cl groups to –N 3 groups by treatment with sodium azide, an appropriate bifunctional cross‐linker is employed to obtain PNPs under CC conditions promoting intra molecular cycloaddition (cross‐linking). Following this new route, polystyrene, poly(alkyl (meth)acrylate), polymethacrylic acid, poly(sodium styrenesulfonate) and poly( N ‐isopropyl) NPs have been synthesized and in‐deep characterized.