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Development of Injectable Biodegradable Multi‐Arms PEG‐Based Hydrogels: Swelling and Degradation Investigations
Author(s) -
Wang David,
Hill David J.T.,
Peng Hui,
Symons Anne,
Varanasi Srinivas,
Whittaker Andrew K.,
Rasoul Firas
Publication year - 2010
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201051033
Subject(s) - self healing hydrogels , swelling , ammonium persulfate , copolymer , peg ratio , materials science , polyethylene glycol , polymer chemistry , swelling capacity , chemical engineering , chemistry , nuclear chemistry , composite material , organic chemistry , polymer , polymerization , finance , engineering , economics
Summary : Injectable biodegradable hydrogels have been developed to determine the efficacy of biomaterials for the treatment of periodontitis through control delivery of bone‐healing bioactives. The hydrogels were prepared from the PEG‐ylated macromer of Boltorn™ H20 (BH20) and an acrylated triblock copolymer of polylactide‐polyethylene glycol (2k)‐polylactide (PLA) in various molar ratios using ammonium persulfate and sodium ascorbate as a free radical initiating system. Preliminary investigations involving the synthesis of PLA hydrogels with different PLLA block lengths were studied in order to determine the swelling ratios and degradation rates of the biodegradable component of the hydrogels prior to copolymerization with BH20. The swelling and degradation studies of PLA with PEG diacrylate (FW 700) hydrogels were established in phosphate buffered saline (PBS) at 37 °C, pH 7.4 and in water (pH ∼5.5). They have been shown to have low swelling ratios (Q max = 4.4 to 3.6) and degradation times of 20–30 days. The swelling and degradation parameters were found to be dependent on the molar ratio of the PEG diacrylate to PLA in the copolymer.