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Photopolymerizable Elastomers for Vascular Tissue Regeneration
Author(s) -
Baudis Stefan,
Steyrer Bernhard,
Pulka Thomas,
Wilhelm Harald,
Weigel Guenter,
Bergmeister Helga,
Stampfl Juergen,
Liska Robert
Publication year - 2010
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201051018
Subject(s) - biocompatibility , materials science , elastomer , photopolymer , regeneration (biology) , diluent , blood vessel , biomedical engineering , composite material , polymerization , chemistry , polymer , medicine , biology , microbiology and biotechnology , psychology , psychiatry , nuclear chemistry , metallurgy
The aim of this study was to design new resin formulations for blood vessel substitutes with small inner diameter that can be 3D‐printed by Additive Manufacturing (AM). Commercially available urethane oligomer acrylates as crosslinking agents (CAs) with different reactive diluents (RDs) and/or thiol chain transfer agents (CTAs) were examined. It could be shown that the properties of photopolymers of carefully selected CA/RD/CTA combinations can be varied in a wide range, also to fit with those of natural blood vessels. Moreover, these materials showed good biocompatibility in in‐vitro cell culture tests with endothelial cells. A new method to assess the tear resistance of the new materials in comparison with natural blood vessels was designed and established. The tear resistance of the developed photopolymers already approaches those of natural material, although there is still need of improvement. The 3D‐structuring of optimized resin system succeeded. Hence AM has proven to be an ideal tool to manufacture parts with the complex structure of natural blood vessels.