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Functionalized Biodegradable Nano‐ and Microspheres for Medical Applications
Author(s) -
Slomkowski Stanislaw
Publication year - 2010
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201050216
Subject(s) - polymer , materials science , monomer , polymerization , chemical engineering , biodegradable polymer , dispersion polymerization , microsphere , macromolecule , drug delivery , polymer chemistry , nano , solvent , nanotechnology , organic chemistry , chemistry , composite material , biochemistry , engineering
Summary: This minireview describes strategies for preparation of biodegradable (from polylactides, and poly(ε‐caprolactone) and from their derivatives) nano‐ and microspheres for medical applications, in particular for drug delivery. In addition to standard methods of particles' formation by emulsification of polymer solution in water‐miscible organic solvent with subsequent solvent evaporation or extraction there are described methods of particles formation by self assembly of polymer macromolecules, by dialysis of polymer solutions in organic water‐miscible solvents carried on against water and by dispersion ring‐opening polymerization of heterocyclic monomers. Strategies for encapsulation of bioactive compounds into nano‐ and microspheres are presented.