Premium
Ultrasound‐Triggered Release of Ibuprofen from a Chitosan‐Mesoporous Silica Composite‐ a Novel Approach for Controlled Drug Release
Author(s) -
Depan Dilip,
Saikia Lakshi,
Singh Raj Pal
Publication year - 2010
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201050111
Subject(s) - chitosan , ibuprofen , drug delivery , mesoporous silica , controlled release , materials science , mesoporous material , chemical engineering , drug , composite number , adsorption , polymer , drug carrier , biomedical engineering , nanotechnology , chemistry , organic chemistry , pharmacology , composite material , medicine , engineering , catalysis
Summary: In this work, an attempt was made to synthesize a novel Chitosan‐Mesoporous silica (CS‐MS) hybrid composite to design a drug delivery system based on ultrasound triggered stimuli‐responsive smart release. The in‐vitro drug release properties of both the Mesoporous Silica (MS) and Chitosan (CS) hybrids were investigated. Ibuprofen (Ibu) was used as a model drug. The results from powder X‐Ray diffraction (XRD) patterns, and BET N 2 adsorption isotherms exhibited that MS can accommodate drug molecules into the lumen of the channels and pores. Drug release, stimulated by temperature and pH of the release media was also investigated. We studied the Ultrasound (US) triggered release of Ibu in a simulated body fluid (pH 7.4). The results exhibited that US can be used as a non‐invasive technique for drug release from polymeric materials. The enhancing effect of ultrasound on drug release is due to the Cavitation effect, without causing any significant destruction on the polymer morphology.