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Native Proteins as Physical Networks: Energy and Geometry Fluctuations and Their Relation to Function
Author(s) -
Erman B.
Publication year - 2011
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.201000118
Subject(s) - globular protein , function (biology) , simple (philosophy) , biological system , energy (signal processing) , protein structure , statistical physics , biophysics , chemistry , chemical physics , physics , biology , crystallography , biochemistry , quantum mechanics , microbiology and biotechnology , philosophy , epistemology
A correspondence between networks and gels, physical or chemical, and native globular proteins is established by visualizing proteins as physical gels. The emphasis is placed on spatial fluctuations of residues in proteins which are correlated, and it is stated that these correlations determine the function of the proteins. Structural and topological features necessary for a gel to exhibit features of a protein such as to perform a predetermined function are discussed. A simple mathematical model that explains the relationships between correlated fluctuations of residues and the function of the protein is given.