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Synthesis of Poly(acrylic acid) Nanogels and Application in Loading and Release of an Oligothiophene Fluorophore and Its Bovine Serum Albumin Conjugate
Author(s) -
Argentiere Simona,
Blasi Laura,
Ciccarella Giuseppe,
Barbarella Giovanna,
Cingolani Roberto,
Gigli Giuseppe
Publication year - 2009
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200950709
Subject(s) - acrylic acid , conjugate , dynamic light scattering , fluorophore , bovine serum albumin , polymer chemistry , acrylate , polymerization , materials science , emulsion polymerization , hydrolysis , emulsion , controlled release , chemical engineering , chemistry , fluorescence , polymer , copolymer , nanoparticle , organic chemistry , chromatography , nanotechnology , mathematical analysis , physics , mathematics , quantum mechanics , engineering , composite material
Summary: Nanometer‐sized poly(acrylic acid) (PAA) hydrogels were synthesized by emulsion polymerization of methyl acrylate and subsequent acid hydrolysis, and their pH‐dependent swelling behaviour was studied by dynamic light scattering. To determine the suitability of PAA nanogels as pH‐sensitive carriers for biomedical applications, loading and release of an oligothiophene fluorophore and its albumin conjugate onto the PAA nanogels were investigated as a function of pH by absorption and photoluminescence measurements. It was observed that loading and release processes of both the oligothiophene and its conjugate could be controlled by changing pH of their solutions.