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Supramolecular Mobility in Polyrotaxanes Exploits Biomedical Functions
Author(s) -
Yui Nobuhiko
Publication year - 2009
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200950524
Subject(s) - supramolecular chemistry , drug delivery , nanotechnology , rotaxane , materials science , ligand (biochemistry) , chain (unit) , chemistry , molecule , receptor , organic chemistry , biochemistry , physics , astronomy
The mobility of cyclodextrins (CDs) threaded onto a linear polymeric chain and the dethreading of the CDs from the chain are the most fascinating features seen in polyrotaxanes. These structural characteristics are very promising to their possible applications in biomedical use. Enhancing multivalent interaction between ligand‐receptor systems by using ligand‐polyrotaxane conjugates is one of the excellent properties related to the CD mobility. Gene delivery using cytocleavable polyrotaxanes is more practical but highly crucial in drug delivery. Such a supramolecular approach using CD‐containing polyrotaxanes is extensively expected to exploit a new paradigm of advanced biomaterials for future medicines.