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Synthesis and Characterization of Chitosan/ Dextran‐Based Hydrogels for Surgical Use
Author(s) -
Liu G.,
Shi Z.,
Kuriger T.,
Hanton L.R.,
Simpson J.,
Moratti S.C.,
Robinson B.H.,
Athanasiadis T.,
Valentine R.,
Wormald P.J.,
Robinson S.
Publication year - 2009
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200950523
Subject(s) - periodate , dextran , chitosan , self healing hydrogels , amine gas treating , chemistry , aldehyde , polymer chemistry , organic chemistry , catalysis
A series of hydrogels were formed from the reaction between an amine functionalized succinyl chitosan and an oxidized dextran. The properties and rate of formation of the gel were related to both the amine and aldehyde levels of the precursors. These levels could be readily changed by altering the reaction conditions, and allowed good control of the gel properties. Oxidation of the dextran with periodate was accompanied by chain scission and a large reduction in molecular weight. The gel showed excellent haemostatic properties and reduction of adhesions in animal models.