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Preparation of Chitosan Based Scaffolds Using Supercritical Carbon Dioxide
Author(s) -
Rinki Kumari,
Dutta Pradip K.,
Hunt Andy J.,
Clark James H.,
Macquarrie Duncan J.
Publication year - 2009
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200950305
Subject(s) - chitosan , supercritical carbon dioxide , fourier transform infrared spectroscopy , formaldehyde , acetic acid , supercritical fluid , solvent , derivative (finance) , materials science , nuclear chemistry , scanning electron microscope , chemical engineering , polymer chemistry , chemistry , organic chemistry , composite material , financial economics , economics , engineering
A novel chitosan‐formaldehyde porous derivative (scaffolds) was prepared by reaction of 85% deacetylated chitosan with 37% aq. formaldehyde using supercritical carbon dioxide (sc. CO 2 ). Prior to reaction, the chitosan hydrogel was prepared in 1% aq. acetic acid (AcOH) and formaldehyde. The prepared hydrogel was subjected to solvent exchange. The identity of the Schiff base was confirmed by Fourier transform infrared spectroscopy (FTIR). The chitosan‐derivative was evaluated by thermal analysis, scanning electron microscopy, and porosimetry analysis. Overall, the sc. CO 2 assisted chitosan derivative opens new perspectives as biomedical material.