Premium
Synthesis, Characterization and Bactericidal Properties of Poly(N‐vinyl‐2‐pyrrolidone‐co‐Maleic anhydride‐co‐N‐Isopropyl acrylamide)
Author(s) -
Talu Muzaffer,
Uzluk Elif,
Yüksel Betül
Publication year - 2010
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200900140
Subject(s) - maleic anhydride , chemistry , polymer chemistry , thermogravimetric analysis , differential scanning calorimetry , gel permeation chromatography , crystallinity , amide , nuclear chemistry , organic chemistry , polymer , copolymer , physics , thermodynamics , crystallography
Summary: Radical‐initiated terpolymerization of maleic anhydride (MA), N‐vinyl‐2‐pyrrolidone (NVP) with N‐isopyropyl acrylamide (NIPA) has been prepared as a way to obtain new water‐soluble polymers. Structure, composition and thermal behaviour of synthesized terpolymers were determined by FTIR, UV‐vis, 1 H NMR spectroscopy, elemental analysis (N content), differential scanning calorimetry, thermogravimetric and differential thermal analysis, gel permeation chromatography analysis (GPC), scanning electron microscopy (SEM) and X‐ray diffraction analysis (XRD). The terpolymer composition‐structure‐property relationship indicates that the semicrystalline structure of terpolymers with different reaction times, degrees of crystallinity, and thermal behaviour depends on the content of carboxyl and amide‐containing monomer linkage. The antimicrobial activities the terpolymers were evaluated against pathogen bacteria: Staphylococcus aureus, Salmonella enteridis, Streptococcucs faecalis , Eschericia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa . The antimicrobial activity was explored by the well‐diffusion technique. All the studied polymers, containing biologically active moieties in the form of ionized cyclic amide and carboxylic acid groups, were more effective against Gram‐positive than Gram‐negative bacteria. The bactericidal effect of terpolymers against Gram negative bacteria increased with the increasing reaction times.