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Ionic Complexes of Biotechnological Polyacids with Cationic Surfactants
Author(s) -
GarcíaAlvarez Montserrat,
de Ilarduya Antxon Martínez,
Portilla José Antonio,
Alla Abdelilah,
MuñozGuerra Sebastián
Publication year - 2008
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200851312
Subject(s) - alkyl , hydrolysis , cationic polymerization , side chain , polyelectrolyte , chemistry , polymer chemistry , polymer , aqueous solution , ionic bonding , polyglutamic acid , polyester , organic chemistry , materials science , ion , biochemistry
Summary: Stoichiometric complexes of biotechnological poly( γ ‐glutamic) acid and poly( β , L ‐malic) acid with alkyltrimethylammonium surfactants of long alkyl chains could be readily prepared in aqueous medium. They adopt a biphasic layered structures in which the main chain and the side chain alternate with nanometric periodicity. Alkyl side chains show reversible melting that involves generation of mesophases. Complexes degraded by water by different mechanisms depending on the constitution of the main chain; the polymalic complexes underwent surface erosion whereas the polyglutamic ones degraded in bulk. Erythromycin could be homogenously loaded into the paraffinic subphase of the complexes and delivered upon incubation under physiological conditions in parallel to the hydrolysis of the polymer.