Premium
Fabrication of Honeycomb‐Structured Poly( DL ‐lactide) and Poly[( DL ‐lactide)‐co‐glycolide)] Films and their Use as Scaffolds for Osteoblast‐Like Cell Culture
Author(s) -
Chaudhuri Julian B.,
Davidson Matthew G.,
Ellis Marianne J.,
Jones Matthew D.,
Wu XuJun
Publication year - 2008
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200851206
Subject(s) - materials science , lactide , chemical engineering , honeycomb , fabrication , solvent , pulmonary surfactant , osteoblast , evaporation , polymer , honeycomb structure , tissue engineering , polymer chemistry , composite material , copolymer , biomedical engineering , chemistry , organic chemistry , medicine , in vitro , biochemistry , alternative medicine , pathology , engineering , physics , thermodynamics
Summary: Surfactant‐free honeycomb‐structured Poly( DL lactide) (P DL LA) and Poly‐( DL lactide‐co‐glycolide) P DL LGA thin films were fabricated by water droplet templating methods. Thin films with uniform pore structure were obtained after controlled evaporation of solvents in a humid atmosphere. Solvent, polymer concentration and humidity were found to be important factors in the formation of honeycomb‐structured thin films. Preliminary cell culture studies with MG‐63 osteoblast‐like cell lines showed promising degrees of cell attachment and proliferation on these films, suggesting that they are applicable as scaffolds for tissue engineering.