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Evaluation of Chitosan/Biphasic Calcium Phosphate Scaffolds for Maxillofacial Bone Tissue Engineering
Author(s) -
Urkmez Aylin Sendemir,
Clark Sherrie G.,
Wheeler Matthew B.,
Goldwasser Michael S.,
Jamison Russell D.
Publication year - 2008
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200850912
Subject(s) - tissue engineering , chitosan , mesenchymal stem cell , biomedical engineering , calcium , scaffold , basic fibroblast growth factor , in vitro , materials science , dentistry , chemistry , growth factor , pathology , medicine , biochemistry , receptor , metallurgy
Porous, 3D chitosan/biphasic calcium phosphate (BCP) scaffolds were used to prepare tissue engineering constructs for maxillofacial bone tissue reconstruction. Mesenchymal stem cells (MSC's) were seeded and cultured on clinically relevant sized scaffolds. In vitro engineered constructs facilitated the healing of mandibular defects in pigs if accompanied with delivery of basic fibroblast growth factor (bFGF).