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Novel Poly(amidoamine)‐Based Hydrogels as Scaffolds for Tissue Engineering
Author(s) -
Emilitri Elisa,
Guizzardi Fabiana,
Lenardi Cristina,
Suardi Marco,
Ranucci Elisabetta,
Ferruti Paolo
Publication year - 2008
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200850608
Subject(s) - poly(amidoamine) , self healing hydrogels , materials science , agmatine , adhesion , bioadhesive , amidoamine , polymer , cell adhesion , tissue engineering , biofabrication , polymer chemistry , substrate (aquarium) , chemical engineering , chemistry , dendrimer , organic chemistry , biomedical engineering , composite material , oceanography , geology , medicine , engineering , putrescine , enzyme
Summary: Poly(amidoamine)s are biocompatible biodegradable polymers, which can be easily functionalized with a number of bioactive and biomimetic compounds. Co‐polymerization of these polymers with 4‐aminobutyl guanidine (agmatine) leads to an RGD mimicking structure. Hydrogels based on this structure showed an enhanced cell adhesion and could be chemically linked to a glass substrate to create a bioadhesive support for cell growth. Preliminary optimization and cell adhesion tests on Madin‐Darby Canine Kidney cells were performed, both on functionalized and non‐functionalized structures, with promising results.