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Monitoring the Interaction of Albumin with a Paclitaxel‐Polymer Conjugate: Complex with Warfarin as Local Probe
Author(s) -
Wunderlich Stefan,
Zähres Manfred,
Jo ByungWook,
Hess Michael
Publication year - 2007
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200751211
Subject(s) - conjugate , paclitaxel , steric effects , warfarin , polymer , albumin , chemistry , materials science , polymer chemistry , stereochemistry , organic chemistry , biochemistry , medicine , mathematics , surgery , chemotherapy , mathematical analysis , atrial fibrillation
Summary: We have used warfarin as a local probe to investigate the orientation of paclitaxel and water soluble polymer conjugates of paxlitaxel in albumin. The relative orientation of warfarin and paclitaxel in a 1:1 complex in solution was investigated by 1 H‐NMR‐spektroskopy (NOESY) and the results are used for the interpretation of the steric situation of paclitaxel respectively the polymer conjugate in albumin.