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Temperature and pH‐Sensitive Polymers with Hydrophobic Spacers for the Controlled Delivery of Drugs
Author(s) -
LiceaClaveríe Angel,
CornejoBravo José Manuel,
SalgadoRodríguez Rodolfo,
SantosRosas Dolores del Rosario,
LugoMedina Eder,
RamosIbarra Marco Antonio,
Arndt KarlFriedrich
Publication year - 2007
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200750843
Subject(s) - self healing hydrogels , swelling , salicylamide , chemistry , polymer , salicylic acid , kinetics , polymer chemistry , methacrylate , chemical engineering , nuclear chemistry , copolymer , organic chemistry , biochemistry , physics , quantum mechanics , engineering
Summary: Acid methacrylates containing hydrophobic aliphatic and aromatic spacers were used to prepare pH‐sensitive ampholytic hydrogels and bidimensional temperature‐ (T) and pH‐sensitive hydrogels. Their swelling behaviour was studied by changing the pH and temperature of buffer solutions. Salicylamide, salicylic acid and green fluorescent protein (GFP) as model drugs were loaded into the gels and their release kinetics studied under simulated gastric and intestinal conditions. T‐ and pH‐sensitive hydrogels containing aliphatic spacers show sustained release of analgesics depending on pH (e.g. 7.4); while longer aliphatic spacers resulted in drug release depending on pH and temperature (T < transition T). GFP was released from temperature‐ and pH‐sensitive ampholytic hydrogels after different lag times depending on hydrogel composition.