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IntelliDrug Implant for Medicine Delivery in Alzheimer's Disease Treatment
Author(s) -
Moscicka Aleksandra E.,
Czarnecka Kinga,
Ciach Tomasz
Publication year - 2007
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200750720
Subject(s) - iontophoresis , buccal administration , buccal mucosa , drug delivery , implant , drug , permeation , biomedical engineering , pharmacology , materials science , medicine , chemistry , dentistry , membrane , nanotechnology , surgery , biochemistry , oral cavity , radiology
Abstract Summary : IntelliDrug it is a denture implant containing a reservoir with drug and making enable a galantamine transport via buccal mucosa by means of iontophoresis. The in vitro experimental studies on drug passive and iontophoretic transport through porcine buccal mucosa were carrying out in horizontal two‐chamber permeation cell with silver electrodes. The drug mass flux was investigated. The influences of initial drug concentration and current density for transport velocity were defined.