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Surface‐Modified Metallic Biomaterials in Contact with Blood and Endothelial Cells
Author(s) -
Walkowiak Bogdan
Publication year - 2007
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200750718
Subject(s) - materials science , titanium , titanium alloy , titanium nitride , surface modification , coating , biocompatible material , metal , nanotechnology , biosensor , nitride , chemical engineering , alloy , biomedical engineering , composite material , metallurgy , layer (electronics) , medicine , engineering
Abstract Summary : The experimental procedures were undertaken in order to characterize of surface‐modified metallic substrates. Results revealed that carbon layers coating the substrates made metallic surface generally more biocompatible and more resistant to biofilm formation. Titanium‐nitride or titanium carbo‐nitride layers on the titanium alloy (Ti6Al4V) allow for modulation of thrombogenity degree of the surface. Our investigations employed several methods: fluorescence and electron microscopy techniques, SPR‐biosensor technology, 2D‐electrophoresis and flow cytofluorymetry.