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The Influence of Crosslinking Amylose‐Methacrylic Acid Graft Copolymers on the Release of BSA
Author(s) -
Silva Itziar,
Gurruchaga Mariló,
Goñi Isabel
Publication year - 2007
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200750711
Subject(s) - copolymer , bovine serum albumin , methacrylic acid , amylose , polymer chemistry , drug delivery , poly(methacrylic acid) , controlled release , chemistry , materials science , chromatography , organic chemistry , polymer , starch , nanotechnology
Summary: One of the biggest challenges in the drug delivery field is to obtain oral systems for the release of peptides and proteins, enabling their use as therapeutic agents for clinical applications. The aim of this work is to obtain biodegradable copolymers suitable for the development of matrices which offer controlled release of proteins to be administered orally.Graft copolymers of amylose‐methacrylic acid were synthesized using different amounts of the crosslinker N, N′‐methylenediacrylamide. The influence on the release profiles of bovine serum albumin (BSA) was researched.