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Synthesis of Calcium Phosphate Nanoparticles in Collagen Medium
Author(s) -
Bertran Celso A.,
Allegretti Lauter J. M.,
Bertazzo Sérgio
Publication year - 2007
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200750710
Subject(s) - crystallinity , calcium , precipitation , nucleation , chemical engineering , phosphate , nanoparticle , matrix (chemical analysis) , chemistry , adsorption , ion , diffusion , apatite , mineralization (soil science) , materials science , inorganic chemistry , mineralogy , chromatography , biochemistry , organic chemistry , thermodynamics , physics , meteorology , nitrogen , engineering
Summary: Mineralization of the proteic matrix composed mostly of collagen type I is controlled by specific interactions of ions Ca 2+ and PO 4 3− , present in the biological fluid, with the matrix, and by the diffusion of these ions. The specific interactions and the diffusion of ions combined; result in the nucleation and formation of calcium phosphate particles. Moreover, they control the morphology, size, crystallinity and composition of the particles. In this work, precipitation of calcium phosphate particles in a collagen matrix type I was carried out through impregnation of the matrix with a Ca 2+ and PO 4 3−solution, with Ca/P ratio 1.67 and pH 2.5. Precipitation of particles associated with matrix structuring was carried out by adsorption of gaseous ammonia.