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New Biodegradable and Thermoresponsive Polymers Based on Amphiphilic Poly(asparagine) Derivatives
Author(s) -
Watanabe Eiji,
Tomoshige Naoki,
Uyama Hiroshi
Publication year - 2007
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200750428
Subject(s) - lower critical solution temperature , amphiphile , polymer , thermoresponsive polymers in chromatography , side chain , polymer chemistry , materials science , phase transition , chemical engineering , phase (matter) , copolymer , chemistry , organic chemistry , composite material , thermodynamics , reversed phase chromatography , physics , engineering
New biodegradable and thermoresponsive polymers based on amphiphilic poly(asparagine) derivatives have been developed. They showed a sol‐gel‐sol phase transition. In particular, not only a phase transition behavior but also a lower critical solution temperature (LCST) was observed in the polymers with N,N ‐dimethylaminopropyl groups as the hydrophilic side chains. The LCST and a sol‐gel‐sol phase transition temperature could be precisely controlled by changing the composition ratio and kind of the hydrophobic and the hydrophilic groups of the side chains in the polymers. These polymers are expected to be applicable for controlled release of drugs, tissue engineering, and others.