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Receptor‐Mediated Gene Delivery Using Chitosan Derivatives in Vitro and in Vivo
Author(s) -
Kim TaeHee,
Jiang HuLin,
Nah JaeWoon,
Cho MyungHaing,
Akaike Toshihiro,
Cho ChongSu
Publication year - 2007
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200750323
Subject(s) - gene delivery , in vivo , transfection , chitosan , genetic enhancement , in vitro , endocytosis , viral vector , biocompatibility , transgene , chemistry , microbiology and biotechnology , biology , receptor , gene , biochemistry , recombinant dna , organic chemistry
The development of an efficient targeted gene delivery system into cells is an important strategy for the advancement of gene therapy. The targeted gene delivery system is especially important in non‐viral gene transfer which shows the relative low transfection efficiency. And it also opens the possibility of selective delivery of therapeutic plasmids to specific tissues. Chitosan has been investigated as a non‐viral vector because it has several advantages such as biocompatibility, biodegradability and low toxicity with high cationic potential. However, low specificity and low transfection efficiency of chitosan need to be overcome prior to clinical trial. In this review, we focused on the specific ligand modification of chitosan for enhancement of cell specificity and transfection efficiency via receptor‐mediated endocytosis in vitro and in vivo .