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The Effects of Co‐Immobilization of Epidermal Growth Factor and Adhesion Factor on the Proliferation of Ligament Cell
Author(s) -
Park YongSoon,
Seo YoungKwon,
Lee HwaSung,
Kwon SoonYong,
Park JungKeug
Publication year - 2007
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200750321
Subject(s) - epidermal growth factor , adhesion , cell growth , cell adhesion , growth factor , cell , chemistry , cell culture , ligament , microbiology and biotechnology , materials science , biophysics , biology , biochemistry , anatomy , genetics , receptor , organic chemistry
The epidermal growth factor and cell adhesion factor were co‐immobilized on a tissue culture plate to allow the proliferation of human ligament cells. The co‐immobilized surfaces were prepared by irradiating a photo‐reactive polypeptide containing azidophenyl‐derivatized side‐chains with UV. The immobilized cell adhesion factor induced initial cell adhesion on the surfaces, and the immobilized cell growth factor appeared to induce cell proliferation. The ligament cells proliferated on the EGF‐immobilized plate until 10 days post‐culture. The co‐immobilization of the epidermal growth factor appears to be an effective method for healing an anterior cruciate ligament through the rapid proliferation of ligament cells.