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Preparation of Polymer/Drug Nano‐ and Micro‐Particles by Electrospraying
Author(s) -
Park Chul Ho,
Kim Min Young,
Yoo Ji Youn,
Kim KiHyun,
Lee JongChan,
Lee Jonghwi
Publication year - 2007
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200750319
Subject(s) - materials science , dispersity , electrohydrodynamics , polymer , fabrication , chemical engineering , nanoparticle , particle size , conductivity , aqueous solution , nanotechnology , nano , particle (ecology) , composite material , polymer chemistry , organic chemistry , chemistry , medicine , alternative medicine , pathology , engineering , oceanography , electrode , geology
The surface energy control capability of electrohydrodynamic force provides electrospraying with various potential advantages such as simple particle size control, mono‐dispersity, high recovery, and mild processing conditions. Herein, particle fabrication of biodegradable polymers using electrospraying was developed. The major processing parameters such as the conductivity of spraying liquids, flow rate, etc., were examined to obtain the successful apparatus configuration of electrospraying. The choice of a consolidation medium was critical in obtaining well‐dispersed nanoparticles. When triphenylphosphate aqueous solution was employed as a consolidation medium, its concentration was not an effective parameter to control the aggregation of primary particles. When organic solvents were employed, the processing windows of electrospraying were relatively narrow than water‐based systems.