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Drug Release Study of Systems Containing the Tragacanth and Collagen Composite: Release Characterization and Viscoelastic Measurements
Author(s) -
Kaffashi B.,
Zandieh A.,
KhadivParsi P.
Publication year - 2006
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200690088
Subject(s) - tragacanth , gelatin , materials science , composite number , rheology , chemical engineering , aqueous solution , composite material , chromatography , chemistry , organic chemistry , food science , engineering
The kinetics of water penetration and pentoxifilline release from both Tragacanth gum and Tragacanth/Collagen matrices has been examined in pure deionised water. The rheological oscillatory measurements of their gel layer obtained by swelling of the imprinted pentoxifilline‐filled polymer matrix with water have been performed. To qualify a polymer for application in drug formulation, appropriate gel stiffness is required. The aqueous solution of Tragacanth does not seem to acquire the actual strength that a hydrogel must retain for this purpose. Thus, along with Tragacanth, gelatin, CaCl 2 and 1, 8 octandiamine curing agent were individually blended in a mixture with Tragacanth gum to improve the gel behavior and drug delivery of the system. The strength of the gel at the body temperature (37 °C) was studied using a cone and plate rheometer. It was found that gelatin could enhance the gel strength of Tragacanth by forming a porous composite. The drug release to an aqueous solution at room temperature was analyzed to be slower for a composite of 1:2 Tragacanth/Collagen.