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Preparation and Characterization of Resorbable Hydrogel Membranes Useful for Tissue Engineering
Author(s) -
Drumond Walker Soares,
RojasCabrera Walter Israel,
Zhao Lili,
de Castro Maria Leonora,
Laganá Dalva Cruz,
Wang Shu Hui
Publication year - 2006
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200651372
Subject(s) - membrane , copolymer , biocompatibility , ethylene glycol , polymer , materials science , chemical engineering , polymer chemistry , tissue engineering , dissolution , ethylene oxide , chemistry , composite material , biomedical engineering , medicine , biochemistry , engineering , metallurgy
New synthetic polymeric membranes of lactic acid were prepared with different chemical composition through copolymerization with ε‐caprolactone and ethylene oxide segments. The prepared copolymers were characterized by hydrogen and carbon‐13 nuclear magnetic resonance ( 1 H‐NMR and 13 C‐NMR) and presented wide range of mechanical properties demonstrated by dynamic mechanical thermal analysis (DMA). Porous membranes were prepared by dissolving the polymer in the presence of salts (NaCl or hydroxyapatite) and/or lower mass poly(ethylene glycol) (Mn = 600 or 1,000 g · mol −1 ). The membranes presented new mechanical and biological characteristics and were suitable for cell penetration, anchorage, differentiation and proliferation. Adherence of cultured fibroblasts on membranes indicates biocompatibility.