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Paclitaxel‐Warfarin Interaction in Solution
Author(s) -
Wunderlich Stefan,
Zähres Manfred,
Jo ByungWook,
Hess Michael
Publication year - 2006
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200651012
Subject(s) - conjugate , paclitaxel , warfarin , albumin , bovine serum albumin , chemistry , aqueous solution , serum albumin , fluorescence , drug , chromatography , heparin , biophysics , biochemistry , pharmacology , organic chemistry , biology , medicine , chemotherapy , surgery , mathematical analysis , physics , mathematics , quantum mechanics , atrial fibrillation
Interactions of a water‐soluble paclitaxel‐polymer conjugate were investigated in aqueous buffer solutions and in the solid state in the presence of model proteins that are abundant in blood serum (bovine serum albumin and human serum albumin). Studies of the intrinsic fluorescence of albumins and extrinsic fluorescence of the albumin/warfarin complex and MALDI‐TOF spectra proved significant interactions of the drug conjugate with the model proteins and warfarin.