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Synthesis of 3‐ and 4‐ Arm Star‐Block Copolypeptides using Multifunctional Amino Initiators and High Vacuum Techniques
Author(s) -
Aliferis Thrasyvoulos,
Iatrou Hermis,
Hadjichristidis Nikos,
Messman Jamie,
Mays Jimmy
Publication year - 2006
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200650802
Subject(s) - dendrimer , ring opening polymerization , polymer chemistry , amine gas treating , polymerization , chemistry , tertiary amine , primary (astronomy) , polymer , organic chemistry , physics , astronomy
Three‐ and four‐arm star‐block copolypeptides, (BL‐b‐G) 3 and (G‐b‐BL) 4 , of poly(ε‐butyloxycarbonyl‐L‐lysine) (BL) and poly(γ‐benzyl‐L‐glutamate) (G), were synthesized under high vacuum conditions, using three different multifunctional amino‐initiators for the ring opening polymerization of the corresponding α‐aminoacid N‐carboxyanhydrides. When the initiator contained only primary amine groups {2(aminomethyl)‐2‐methyl‐1,3‐propanediamine, AMPDA}, well‐defined star‐block copolypeptides with monomodal molecular weight distribution were produced. However, if the multifunctional initiator contained both primary and tertiary amine groups {polypropylenimine tetraamine dendrimer, generation 1.0 (DAB); amidoethylethanolamine dendrimer, 1,4‐diaminobutane core, generation 0.0 (PAMAM)}, bimodal high polydispersed copolypeptides were formed. The different behaviors are due to the participation of both the primary and tertiary amino groups, each following different polymerization kinetics.