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Use of Natural Monomer in the Synthesis of Nano‐ and Microparticles of Polyurethane by Suspension‐Polyaddition Technique
Author(s) -
ZanettiRamos Betina,
Soldi Valdir,
LemosSenna Elenara,
Borsali Redouane
Publication year - 2005
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200551129
Subject(s) - polyurethane , polyol , ethylene glycol , isocyanate , materials science , castor oil , polymer chemistry , chemical engineering , nanoparticle , scanning electron microscope , fourier transform infrared spectroscopy , ethylene oxide , dynamic light scattering , polymer , chemistry , organic chemistry , copolymer , composite material , nanotechnology , engineering
Summary: Polyurethane nano‐ and microparticles were synthesized by suspension‐polyaddition technique, using aqueous polymerization medium. Castor oil, a vegetable triglyceride possessing hydroxyl groups was used as natural polyol and methylene diphenyl diisocyanate (MDI) as isocyanate. The levofloxacin, an antibacterial drug was used as model drug to measure the particles encapsulation efficiency. The effect of the addition of a second polyol, the poly(ethylene glycol) (PEG), and the stirring rate on the mean diameter and morphology of particles was also investigated. The poly(ethylene glycol) has an important effect in the reduction of particles size and their porosity. On the other hand, the poly(ethylene glycol) reduced the yield of encapsulation from 70% for the formulation without PEG to 20% for formulations with PEG. FTIR analysis confirmed the polyurethane formation. Dynamic light scattering study, transmission electron microscopy (TEM) and scanning electron microscopy (SEM) were used to determine the nanoparticles size and shape. Spectrofluorimetric analysis was used to detect the levofloxacin.