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Multi‐Material Scaffolds for Tissue Engineering
Author(s) -
Darling Andrew,
Shor Lauren,
Khalil Saif,
Mondrinos Mark,
Lelkes Peter,
Guceri Selcuk,
Sun Wei
Publication year - 2005
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200550935
Subject(s) - scaffold , tissue engineering , materials science , biocompatible material , fibrin , biomedical engineering , nanotechnology , engineering , immunology , biology
A trend in developing biocompatible scaffolds for tissue engineering has been to seek an ideal single material for which a given cell type will exhibit favorable behavior. While an ideal single material has proven elusive, scaffold manufacture using combinations of specialist materials can produce more versatile structures. By controlling the percentage and architecture of material components, mechanical properties, cell attachment, and proliferation may be optimized for a given function. Three specialist materials, poly‐ϵ‐caprolactone (PCL), fibrin, and alginate, were incorporated into multi‐component scaffolds for a series of experiments testing each component with culture of fibroblasts. The rigid and formable PCL provided structure, the fibrin pore‐filler allowed for cell attachment, and alginate thread provided a nutrient transfer pathway in lieu of a vascular system. The efficacy of these scaffolds was judged on fibroblast distribution and population after 7‐12 days of culture.