Premium
Imaging Therapeutic Proteins in Gelatin for Controlled Drug Release
Author(s) -
Wagoner Johnson Amy,
Serrano Nilda Juan,
Whittington Morgan Abby,
Jamison Russell,
Choy Young Bin,
Choi Hyungsoo,
Kim Kyekyoon Kevin,
DeCarlo Francesco
Publication year - 2005
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200550929
Subject(s) - gelatin , chemistry , trypsin , colloidal gold , drug , trypsin inhibitor , nanoparticle , synchrotron , biomedical engineering , radiochemistry , materials science , biochemistry , nanotechnology , pharmacology , enzyme , medicine , physics , nuclear physics
Preliminary results from this study show that x‐ray microcomputed tomography can be used to image model proteins for bone inducing growth factors. Small quantities (<1 μg protein/mg gelatin) of soybean trypsin inhibitor labeled with either gold nanoparticles or nonradioactive iodine were detected using synchrotron radiation. These results could lead to a new method of measuring the release profile of therapeutic proteins.