Imaging Therapeutic Proteins in Gelatin for Controlled Drug Release | Zendy

Wagoner Johnson Amy | Zendy; Serrano Nilda Juan | Zendy; Whittington Morgan Abby | Zendy; Jamison Russell | Zendy; Choy Young Bin | Zendy; Choi Hyungsoo | Zendy; Kim Kyekyoon Kevin | Zendy; DeCarlo Francesco | Zendy

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Imaging Therapeutic Proteins in Gelatin for Controlled Drug Release

Author(s) -

Wagoner Johnson Amy,

Serrano Nilda Juan,

Whittington Morgan Abby,

Jamison Russell,

Choy Young Bin,

Choi Hyungsoo,

Kim Kyekyoon Kevin,

DeCarlo Francesco

Publication year - 2005

Publication title -

macromolecular symposia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.257

H-Index - 76

eISSN - 1521-3900

pISSN - 1022-1360

DOI - 10.1002/masy.200550929

Subject(s) - gelatin , chemistry , trypsin , colloidal gold , drug , trypsin inhibitor , nanoparticle , synchrotron , biomedical engineering , radiochemistry , materials science , biochemistry , nanotechnology , pharmacology , enzyme , medicine , physics , nuclear physics

Preliminary results from this study show that x‐ray microcomputed tomography can be used to image model proteins for bone inducing growth factors. Small quantities (<1 μg protein/mg gelatin) of soybean trypsin inhibitor labeled with either gold nanoparticles or nonradioactive iodine were detected using synchrotron radiation. These results could lead to a new method of measuring the release profile of therapeutic proteins.

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