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Controlled Release from and Tissue Response to Physically Bonded Hydrogel Nanoparticle Assembly
Author(s) -
Hu Zhibing,
Xia Xiaohu,
Marquez Manuel,
Weng Hong,
Tang Liping
Publication year - 2005
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200550927
Subject(s) - biocompatibility , nanoparticle , dextran , polymer , materials science , acrylic acid , aqueous solution , chemical engineering , dispersion (optics) , interpenetrating polymer network , polymer chemistry , copolymer , nanotechnology , chemistry , composite material , chromatography , organic chemistry , physics , optics , engineering , metallurgy
Our recent work on synthesis and application of thermally gelling nanoparticle dispersions is briefly reviewed here. These nanoparticles consist of interpenetrating polymer networks (IPN) of poly‐acrylic acid (PAAc) and poly( N ‐isopropylacrylamide) (PNIPAM). The aqueous IPN nanoparticle dispersions with polymer concentrations above 2.5 wt % underwent an inverse thermoreversible gelation at about 33 °C. Dextran markers of various molecular weights as model macromolecular pseudodrugs were mixed with the IPN nanoparticle dispersion at room temperature. At body temperature, the dispersion became a gel. The dextran release profiles were then measured using UV‐visible spectroscopy. The biocompatibility of this nanoparticle assembly was assessed using an animal implantation model.