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Spontaneously Forming Unilamellar Phospholipid Vesicles
Author(s) -
Yue Baohua,
Huang ChienYueh,
Nieh MuPing,
Glinka Charles J.,
Katsaras John
Publication year - 2004
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200550111
Subject(s) - vesicle , phospholipid , lipid bilayer , neutron scattering , bilayer , small angle neutron scattering , liposome , lipid vesicle , dynamic light scattering , chemistry , materials science , analytical chemistry (journal) , scattering , chromatography , membrane , optics , nanotechnology , biochemistry , physics , nanoparticle
Abstract Unilamellar vesicles (ULV) consisting of a single lipid bilayer are of special interest as drug delivery vehicles. Here, we report on a spontaneously forming ULV system composed of the short‐ and long‐chain phospholipids, dihexanoyl (DHPC) and dimyristoyl (DMPC) phosphorylcholine, respectively, doped with the negatively charged lipid, dimyristoyl phosphorylglycerol (DMPG). Small‐angle neutron scattering (SANS) and dynamic light scattering (DLS) were employed to systematically investigate the effects of lipid concentration, salinity, and time on vesicle stability. It is found that ULV size is practically constant over a range of lipid concentration and temperature. The spontaneously formed ULV are stable for periods of four months, or greater, without the use of stabilizers.