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Synthesis and Characterization of β ‐Poly(glucose‐amine)‐N‐(2,3‐dihydroxypropyl) Derivatives as Medical Care and Biological Joint Material. Family 2. Tri or Tetra‐Sulfated β ‐Chitosan
Author(s) -
Youn Ryu Ga,
Ryual Ryu Soung,
Doung Jang Hang,
Uk Jo Byeong
Publication year - 2004
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200451206
Subject(s) - chitosan , chitin , glucosamine , tetra , polysaccharide , chelation , amine gas treating , chemistry , biological activity , chemical structure , polymer , polymer chemistry , nuclear chemistry , organic chemistry , medicinal chemistry , biochemistry , in vitro
Chitin is a natural polysaccharide by N‐acetyl‐D‐glucosamine units β(1‐4) linked. In the present work a chitosan with DA 56% and Mv 80.000 g/mol will be employed. Several techniques to obtain sulphate derivatives of chitin and to chitosan have been proposed due to the interesting biological and chemical properties of such as heparin compounds. Among others it could be mentioned their antibactericidal and metal chelating properties. In the present work a new sulfated derivatives of chitosan with potential growth regulator properties were obtained. The reaction was carried out in heterogeneous media using a commercial growth regulator ‐SO 3 H as sulfating agent. All derivatives were characterized by several spectroscopic techniques. In IR spectra the bands at 1240 cm −1 , (S=O stretching) and 860 cm −1 , corresponding to S‐O‐C symmetric stretching, are characteristic of sulphates groups. In 1 H‐NMR spectra the appearance of functional group signal confirm its structure.