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Artificial metallo‐DNA towards discrete metal arrays
Author(s) -
Shionoya Mitsuhiko
Publication year - 2004
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200450503
Subject(s) - nucleobase , oligonucleotide , molecular magnets , crystallography , unpaired electron , base pair , metal , materials science , metal ions in aqueous solution , dna , dna origami , pairing , nanotechnology , molecule , stereochemistry , chemistry , magnetization , physics , nanostructure , magnetic field , metallurgy , biochemistry , superconductivity , organic chemistry , quantum mechanics
DNA shows promise as a provider of a structural basis for the “bottom‐up” fabrication of functionalized molecular building blocks. In particular, the replacement of hydrogen‐bonded DNA base pairing for alternative one could possibly provide a novel tool for re‐engineering DNA as well as for biological applications. This review describes our recent approaches to metal‐based strategy directed towards self‐assembled metal arrays within DNAs. Recently, we reported the synthesis of a series of artificial oligonucleotides, d(5′‐G H n C‐3′) ( n = 1‐5), using hydroxypyridone nucleobases ( H ) as flat bidentate ligands. Right‐handed double helices of the oligonucleotides, n Cu 2+ ·d(5′‐G H n C‐3′) 2 ( n = 1‐5), are quantitatively formed through Cu 2+ ‐mediated alternative base pairing ( H ‐Cu 2+ ‐ H ), where the Cu 2+ ions are aligned along the helix axes inside the duplexes with the Cu 2+ ‐Cu 2+ distance of 3.7 ± 0.1 Å. The Cu 2+ ions are coupled in a ferromagnetic manner with one another through unpaired d electrons to form magnetic chains. This strategy represents a new method for self‐assembled metal arrays in a predesigned fashion, leading to the possibility of metal‐based molecular devices such as molecular magnets and wires.