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Novel swelling/shrinking behaviors of glucose‐binding hydrogels and their potential use in a microfluidic insulin delivery system
Author(s) -
Siegel Ronald A.,
Gu Yuandong,
Baldi Antonio,
Ziaie Babak
Publication year - 2004
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200450322
Subject(s) - self healing hydrogels , swelling , microfluidics , insulin , chemistry , biophysics , glucose transporter , mechanism (biology) , materials science , nanotechnology , polymer chemistry , composite material , biology , microbiology and biotechnology , epistemology , philosophy
Hydrogels based on lightly crosslinked poly(methacrylamidophenylboronic acid‐co‐acylamide) swell monototically at pH 7.4 with exposure to increasing concentrations of glucose. At pH 10 these hydrogels first shrink and then reswell with increasing glucose concentration. A mechanism for these disctinct behaviors is proposed and preliminary results validating this mechanism are presented. A simple microfabricated glucose‐sensitive valve based on this hydrogel is described.