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Temperature‐responsive, polymer‐modified surfaces for green chromatography
Author(s) -
Kikuchi Akihiko,
Okano Teruo
Publication year - 2004
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200450319
Subject(s) - thermoresponsive polymers in chromatography , aqueous solution , hydrophilic interaction chromatography , polymer , ionic bonding , hydrophobic effect , poly(n isopropylacrylamide) , phase (matter) , ionic strength , chromatography , chemistry , matrix (chemical analysis) , materials science , chemical engineering , high performance liquid chromatography , organic chemistry , copolymer , ion , engineering
Thermoresponsive poly( N ‐isopropylacrylamide) (PIPAAm) and its derivatives were utilized as chromatography column matrix modifiers to develop novel supports for thermoresponsive hydrophobic chromatography with aqueous mobile phase. In the column, matrix surfaces show thermoresponsive hydrophilic/hydrophobic property alterations, which alter interaction with and retention of solutes to be separated. We have also demonstrated that the electrostatic interaction of ionic solutes and charged, thermoresponsive polymer‐modified surfaces can be modulated temperature changes in the aqueous mobile phase alone.