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Cell sheet engineering: intelligent polymer patterned surfaces for tissue engineered liver
Author(s) -
Harimoto Masami,
Yamato Masayuki,
Kikuchi Akihiko,
Okano Teruo
Publication year - 2003
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200390127
Subject(s) - tissue engineering , cell culture , hepatocyte , materials science , microbiology and biotechnology , tissue culture , polymer , liver tissue , biomedical engineering , cell , surface engineering , nanotechnology , chemistry , composite material , in vitro , biology , engineering , medicine , biochemistry , genetics
We describe a new culture system utilizing the temperature‐responsive polymer grafted surface for designing of cell position and layered tissue reconstruction. Organizing of the hepatic tissue structure by controlling the culture system, that is patterned co‐culture and layered cell sheet co‐culture achieved by moving the cultured cells from the culture surface, resulted in regulation of the hepatocyte function. The technique for cell sheet manipulation would promote the liver tissue engineering in quality.