Premium
Polymer‐modification of an anti‐cancer drug: effects on hydrodynamic properties
Author(s) -
Sohn JungSun,
Choi SooKyung,
Jo ByungWook,
Hess Michael,
Zähres Manfred
Publication year - 2003
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200351119
Subject(s) - polymer , ethylene oxide , materials science , macromolecule , viscosity , rigidity (electromagnetism) , chemical engineering , polymer chemistry , chemistry , copolymer , composite material , biochemistry , engineering
Coupling of a hydrophobic pharmaceutical agents with the hydrophilic poly(ethylene oxide) chain can make the drug water soluble which is necessary for some applications. The modification of the polymer chain results in a different solution behaviour of the macromolecules compared with the unmodified polymer. There are strong indications that shape and rigidity of the modified molecule differ significantly from the simple chain. Some results from measurements of the self‐diffusion coefficient and solution viscosity are discussed. The results are important for further engineering on active drug systems.