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Synthesis of novel graft polyhydroxyalkanoates
Author(s) -
Renard Estelle,
Tanguy PierreYves,
Samain Eric,
Guerin Philippe
Publication year - 2003
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.200350702
Subject(s) - polyhydroxyalkanoates , polyester , ethylene glycol , polymer chemistry , peg ratio , copolymer , condensation polymer , polymer , grafting , size exclusion chromatography , biodegradation , chemistry , solvent , lactic acid , biodegradable polymer , materials science , organic chemistry , genetics , finance , bacteria , biology , economics , enzyme
Graft copolymers were synthesized by direct condensation of methoxy‐poly(ethylene glycol) (MePEG) or methoxy‐poly(lactic acid) (MePLA) onto a reactive polyhydroxyalkanoate (PHA) backbone in organic solvent. Side carboxylic groups of the PHA were coupled with end hydroxyl groups of MePEG or MePLA in the presence of N,N′‐dicylohexylcarbodiimide (DCC). Graft copolymers were characterized by 1 H NMR spectroscopy and size exclusion chromatography (SEC). NMR spectra of PHA‐ g ‐PEG and PHA‐ g ‐PLA showed the presence of significant amounts of PEG and PLA, respectively. No noticeable unreacted PEG or PLA were detected in SEC chromatograms. Grafting of hydrophilic polymers chains as PEG or biodegradable oligomers as PLA onto PHA backbone will generate polyesters with a more rapid water uptake and faster biodegradation rates. These PHA polymers conjugates could be interesting for bioactive agent delivery systems.