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Resorbable initiators for polymerizations of lactones
Author(s) -
Kricheldorf Hans R.,
KreiserSaunders Ingrid,
Damrau DirkOlaf
Publication year - 1999
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.19991440124
Subject(s) - chemistry , iodide , hydroxide , lactide , polymer chemistry , reactivity (psychology) , stearate , reagent , ring opening polymerization , hemin , chloride , nuclear chemistry , organic chemistry , monomer , copolymer , polymer , heme , enzyme , medicine , alternative medicine , pathology
Numerous salts were prepared from cations and anions belonging to the human metabolism, such as Na, K, Mg, Ca, Zn and Fe in combination with chloride, iodide, hydroxide, carbonate, acetate, stearate, glycolate, L‐lactate, D‐mandelate and various N‐substituted α‐amiono acids. All these salts were used as initiators for polymerizations of L‐lactide in bulk at 100–180°C. Furthermore, Grignard reagents, hemin and hematin were included in this study. Zn L‐lactate was found to be the most useful initiator in terms of reactivity, maximum molecular weight of the isolated poly(L‐lactide) and its optical purity. Zn L‐lactate initiated copolymerizations of L‐lactide and glycolide or ϵ‐caprolactone were also studied.