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Kinetics and mechanism of biodegradation of (co)polyglycolide sutures
Author(s) -
Belenkaya Bronislava G.,
Sakharova Valentina I.,
Sinevich Eugene A.,
Belousov Sergej I.,
Kuptsov Albert H.,
Chvalun Sergei N.
Publication year - 1999
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.19991440117
Subject(s) - differential scanning calorimetry , biodegradation , polymer , materials science , chemical engineering , fourier transform infrared spectroscopy , copolymer , hydrogen bond , polymer chemistry , chemistry , composite material , molecule , organic chemistry , thermodynamics , physics , engineering
Biodegradation in vivo of modified and unmodified PG (polyglycolide) and PGL (copolymer glycolide — L — lactide) monofilament sutures were studied using 1 H‐ NMR, wide and small angle X‐ray scattering, differential scanning calorimetry (DSC), electron microscopy (EM), Fourier transform (FT) Raman spectroscopy methods. It was found that the process includes a steady‐state and accelerated stages of biodegradation. The suture biostability depends on polymer morphology changing widely over the suture draw ratio. The modification of polymer chain results in an increase in suture useful lifetime without significant changes of complete polymer degradation time. It was also established the important role of weak intermolecular hydrogen bonds such as CH–‐O=C in the suture stability.