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Degradation of oligo(lactone) branches linked to poly(methacrylate) networks
Author(s) -
Seidel Peter,
Sandner Barbara,
Gopp Udo,
Schöch Martin,
Steurich Simone,
Santerre J. Paul
Publication year - 1999
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.19991440115
Subject(s) - hydrolysis , degradation (telecommunications) , aqueous solution , lactone , copolymer , methacrylate , high performance liquid chromatography , composite number , nuclear chemistry , materials science , chemical decomposition , chemistry , polymer chemistry , chromatography , organic chemistry , decomposition , composite material , polymer , telecommunications , computer science
Partially resorbable composite materials were developed for bone applications and were prepared by crosslinking copolymerization of oligo(lactone) macromonomers with selected comonomers in the presence of hydroxy apatite. The composites were incubated in aqueous solution of different pH and electrolyte content over a period up to 300 days. The percentage of the released hydroxycarboxylic acid from the oligo(lactone) branches was determined by the titration or by high performance liquid chromatography (HPLC). A catalytic influence of cholesterol esterase (CE) on the hydrolysis of the materials was observed. Determination of CE activity in the presence of the different composite materials showed that the half‐life time of CE was the lowest in the presence of the material undergoing the fastest degradation. After degradation the composite materials have preserved their coherence and have shown higher glass transition temperatures in the dried state than the materials before degradation.