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Synthetic and natural polymers as drug carriers for tuberculosis treatment
Author(s) -
Batyrbekov Erkesh O.,
Iskakov Rinat,
Zhubanov Bulat A.
Publication year - 1998
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.19981270132
Subject(s) - polymer , polyvinyl alcohol , drug , ethionamide , isoniazid , drug delivery , drug carrier , chemistry , materials science , combinatorial chemistry , organic chemistry , tuberculosis , pharmacology , medicine , ethambutol , pathology
Drug forms based polymer carriers of prolong action were created for toxicologic effect of drug to be reduced in spite of long treatment of diseases. In present work a number of synthesis and natural polymers have been studied as carriers of antituberculous drugs for controlled delivery application. Following as drugs as isoniazid and ethionamide were incorporated into polymeric matrix (segmented polyurethanes, polyvinyl alcohol) and chemically bound with the polymer chain by covalent or electrostatic forces (aldehyde‐ and carboxymethylderivatives of polysaccharides). Biodegradation of polymeric systems and the release of drugs were studied by various physico‐chemical methods. It was shown that the drug release depends of method of the immobilization, type of the drug/polymer bonding, drug loading. The bacteriostatic activity of obtained systems was determined. The possibility of tuberculosis treatment was proved in experiments of animals.