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Polymer‐drug conjugates: Manipulation of drug delivery kinetics
Author(s) -
Pitt Colin G.,
Wertheim Jason,
Wang C. T.,
Shah Subodh S.
Publication year - 1997
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.19971230122
Subject(s) - kinetics , polymer , lower critical solution temperature , conjugate , solvolysis , chemistry , hydrolysis , polymer chemistry , reaction rate constant , chemical engineering , materials science , organic chemistry , copolymer , mathematical analysis , physics , mathematics , quantum mechanics , engineering
Three methods of manipulating the kinetics of hydrolysis of polymer conjugates were evaluated. It was demonstrated that either first‐order, zero‐order or S‐shaped kinetic profiles could be achieved by systematic changes in the chemical composition of several series of model side‐chain substituted polyacrylates. The changes in kinetics were shown to arise from an increase in the rate constant during solvolysis, resulting from predictable changes in either the water content, secondary structure, or LCST of the polymer conjugate.