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Preparation and anticoagulant surface properties of glucoside‐ or sulfated glucoside‐bearing polymer grafted poly(ethylene) films
Author(s) -
Sakamoto Nobuyuki,
Shioya Tomoko,
Kishida Akio,
Akashi Mitsuru
Publication year - 1997
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.19971200117
Subject(s) - glucoside , adhesion , chemistry , adsorption , sulfation , sulfate , polymer chemistry , materials science , biophysics , biochemistry , organic chemistry , medicine , alternative medicine , pathology , biology
Poly(GEMA) or poly(GEMA)‐sulfate grafted surfaces were prepared for the purpose of developing biomaterials with anticoagulant surfaces. Their functionalities were investigated as anticoagulant activity, proteins and cells adhesion activity, and complement activation activity. These results revealed that the adhesion of blood cells onto a GEMA‐sulfate grafted surface was due to protein adsorption and that complement activation onto a GEMA‐sulfate grafted surface was larger than that on a GEMA grafted surface. A GEMA‐sulfate grafted surface, however, exhibited good anticoagulant activity. These functions seemed to be due to the specific functionality of the SO 3 groups in a GEMA‐sulfate.