Premium
Macromolecules in ordered media. 6. Effect of the phospholipidic bilayer composition on poly (2‐vinyl pyridine) ‐ liposome association
Author(s) -
Porcar Iolanda,
García Rosa,
Soria Vicente,
Abad Concepción,
Campos Agustín
Publication year - 1997
Publication title -
macromolecular symposia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 76
eISSN - 1521-3900
pISSN - 1022-1360
DOI - 10.1002/masy.19971190125
Subject(s) - liposome , phospholipid , membrane , bilayer , macromolecule , pyridine , polymer , lipid bilayer , biophysics , fluorescence , chemistry , synthetic membrane , materials science , organic chemistry , biochemistry , biology , physics , quantum mechanics
The intrinsic fluorescence emission of poly (2‐vinyl pyridine) has been exploited in order to gain insight into the nature of the interaction with artificial membranes. In this contribution, the study has been focused on the effect of the phospholipid bilayer composition on the association to the polymer. Fluorescence data have been converted into association isotherms and then analyzed in terms of both binding and partition models. Results show that the association is enhanced by the presence of negative charged phospholipid as a constituent of the liposomal membrane. The strong surface density dependence of the polymer‐liposome association indicates the predominantly electrostatic nature of that interaction.